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KMID : 1094720070120060662
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Biotechnology and Bioprocess Engineering
2007 Volume.12 No. 6 p.662 ~ p.667
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Regulation of proteins related to melanogenesis by heartwood extract of Morus bombycis using proteome analysis
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Yoo Byoung-Sam
Yoo Mi-Ae
Song Young-Keun
Byun Sang-Yo
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Abstract
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The ability of heartwood extract ofMorus bombycis in controlling the melanogenesis in B16 melanoma was investigated. An inhibitory effect was observed when the dose concentration was less than 10 mg/L. When the dose was 10 mg/L, the extracellular melanin accumulated was only 5% of the control. Proteome analysis with 2-D PAGE and MALDI-TOF showed that there were various proteins involved in inhibitory melanogenesis. It seems that down-regulation of TRP2, vacuolar protontranslocating ATPase 100 kDa subunit isoform a1-I and V-ATPase E2 subunit were involved in melanosome development and regulation that could reduce melanin synthesis.
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KEYWORD
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Morus bombycis, melanogenesis, proteome analysis
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